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P53 mutation is associated with multiple copies of mutant p53 allele and with chromosomal instability in non-small cell lung carcinoma (NSCLC)

✍ Scribed by Franklin, W.A; Berezuk, M; Anderson, M.A; Mault, J; Pomeranz, M; Wiest, J; Varella-Garcia, M


Book ID
118570141
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
211 KB
Volume
29
Category
Article
ISSN
0169-5002

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## Background: An accumulation of mutations can result in carcinogenesis. comparing genetic alterations in preneoplastic lesions with those seen in cancer in the same patient may be helpful in the early diagnosis of lung carcinoma or preneoplastic lesions. ## Methods: To identify genetic alterati