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p53 Interference and Growth Inhibition in p53-Mutant and Overexpressing Endometrial Cancer Cell Lines

✍ Scribed by Mike F. Janicek; Roberto Angioli; Ayçe D. Unal; Bernd-Uwe Sevin; Marilu Madrigal; Ricardo Estape; Hervy E. Averette


Book ID
115617213
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
612 KB
Volume
66
Category
Article
ISSN
0090-8258

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The putative tumor suppressor gene p53 plays a key role in the regulation of cell proliferation. Functional loss of p53 protein through mutation or viral oncogene-complexing can result in p53 protein overexpression detectable by immunocytochemistry, which in turn has been associated with markers of