p53-independent upregulation of p21WAF1 in NIH 3T3 cells malignantly transformed by mot-2
β Scribed by TAKANO, Syuichi; WADHWA, Renu; MITSUI, Youji; KAUL, Sunil C
- Book ID
- 110020431
- Publisher
- Nature Publishing Group
- Year
- 2001
- Tongue
- English
- Weight
- 201 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0007-0610
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Histone deacetylase inhibitor-induced expression of p21 WAF1 is p53 independent. In the present study, we provide evidence that trichostatin A (TSA), a specific inhibitor of histone deacetylase, can elevate H3 and H4 acetylation and p21 WAF1 expression in NIH3T3 cells at first. To identify the trans
Codon 273 is one of the hot spots of missense mutation of the p53 tumor suppressor gene found in human cancers. We have previously reported that a mutation at codon 273, p53-273L (Arg 3 Leu), suppresses cell growth despite its having no p53-specific transactivation activity. To further elucidate the