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p53-independent upregulation of miR-34a during oncogene-induced senescence represses MYC

✍ Scribed by Christoffersen, N R; Shalgi, R; Frankel, L B; Leucci, E; Lees, M; Klausen, M; Pilpel, Y; Nielsen, F C; Oren, M; Lund, A H

Book ID: 109841179
Publisher: Nature Publishing Group
Year: 2009
Tongue: English
Weight: 445 KB
Volume: 17
Category: Article
ISSN: 1350-9047
DOI: 10.1038/cdd.2009.109

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## Abstract Binding of p53 to miR‐34a promoter activates the expression of tumor‐suppressive miR‐34a. Oncogenic human papillomavirus (HPV) infection downregulates miR‐34a expression through viral E6 degradation of p53. In our report, we found that miR‐34a specifically targets p18Ink4c, a CDK4 and C