p53 Gene Mutations in Pontine Gliomas of Juvenile Onset
β Scribed by S.J. Zhang; X.L. Feng; H. Koga; T. Ichikawa; S. Abe; T. Kumanishi
- Book ID
- 115573701
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 360 KB
- Volume
- 196
- Category
- Article
- ISSN
- 0006-291X
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Loss of p53 function is involved in tumorigenesis of various human cancers, but the relation between mutation of the p53 tumor-suppressor gene and the chemo-and radiosensitivity of tumors remains unclear. Mutated p53 gene in malignant glioma is often associated with progression and recurrence of rna
## Abstract Epidemiological studies on intracranial tumors have suggested that the observed familial aggregation of a proportion of gliomas may be due to inherited predisposition to their development. In the LiβFraumeni syndrome (LFS) associated with germβline mutations of the __p53__ gene, nervous