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p53 Gene Mutations Associated with Anaplastic Transformation of Human Thyroid Carcinomas

โœ Scribed by Nakamura, Tsutomu ;Yana, Ikuo ;Kobayashi, Tetsuro ;Shin, Eisei ;Karakawa, Katsu ;Fujita, Shoichi ;Miya, Akihiro ;Mori, Takesada ;Nishisho, Isamu ;Takai, Shin-ichiro


Book ID
108579598
Publisher
Wiley (Blackwell Publishing)
Year
1992
Tongue
English
Weight
390 KB
Volume
83
Category
Article
ISSN
0910-5050

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Involvement of p53 gene mutations in hum
โœ Tsuyoshi Honda; Hidenori Kato; Toshiro Imamura; Tomonao Gima; Jun-Ichi Nishida; ๐Ÿ“‚ Article ๐Ÿ“… 2009 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 1019 KB

Mutations in the p53 gene are associated with a wide variety of human malignancies. Point mutation in one allele and loss of the remaining one generally lead to inactivation of p53 protein. A high frequency of allelic losses corresponding to the I7p 13.3 region that contained the p53 gene sequence