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p53 gene mutation in N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder tumors and N-methyl-N-nitrosourea-induced colon tumors of rats

โœ Scribed by Hongzhong Min; Eiji Kudo; Akiko Hino; Katsuhiko Yoshimoto; Hiroyuki Iwahana; Mitsuo Itakura; Keisuke Izumi


Book ID
117468524
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
328 KB
Volume
117
Category
Article
ISSN
0304-3835

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Chemotherapeutic agents were evaluated for effect on the development of urinary bladder tumors induced by N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) in male Wistar strain rats. Seven hundred and two rats were given 0.05% BBN in drinking water for 8 weeks. After BBN treatment, the animals were divi