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p53 Gene deletions in paraffin-preserved lymphoid tumors from irradiated mice

✍ Scribed by Tatjana Paunesku; Yueru Zhang; M.Anne Gemmell; Gayle E. Woloschak

Book ID: 114118834
Publisher: Elsevier Science
Year: 2000
Tongue: English
Weight: 142 KB
Volume: 24
Category: Article
ISSN: 0145-2126
DOI: 10.1016/s0145-2126(00)00005-9

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## Abstract Deletion of the tumor suppressor gene p53 has been shown to improve the outcome in experimental models of focal cerebral ischemia and kainate‐induced seizures. To evaluate the potential role of p53 in traumatic brain injury, genetically modified mice lacking a functional p53 gene (p53^–