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p53 expression and proliferative activity predict survival in non-invasive thymomas

โœ Scribed by Achille Pich; Roberto Chiarle; Luigi Chiusa; Renata Ponte; Massimo Geuna; Giorgio Palestro

Book ID
101233549
Publisher
John Wiley and Sons
Year
1996
Tongue
French
Weight
445 KB
Volume
69
Category
Article
ISSN
0020-7136

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โœฆ Synopsis

We performed p53 immunohistochemistry, DNA flow cytometry and analysis of the argyrophilic nucleolar organizer regions (AgNORs) in formalin-fixed, paraffin-embedded sections from 46 non-invasive thymomas and correlated the results with the traditional clinicopathologic features of the tumor. p53 immunopositivity was detected in 2 I of 46 cases; it was not associated with any clinicopathologic features nor DNA content but significantly correlated with AgNOR counts. On univariate analysis, 10-year survival rates were 100% for p53-negative cases but only 71% for p53-positive cases and 93% for patients with low AgNOR counts but only 77% for patients with high AgNOR counts. Age, sex, histologic type, myasthenia gravis and DNA content did not correlate with survival. Our results indicate that p53 staining and evaluation of proliferative activity allow assessment of prognosis in non-invasive thymomas, when all of the other parameters are insufficient. Furthermore, the high rate of p53 expression in non-invasive thymomas suggests that abnormal p53 immunoreactivity may occur early in the neoplastic process.

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