A portion of fetal germ cells undergoes apoptosis in the physiological context, but the molecular mechanisms of their apoptosis are largely unknown. Because p53 tumor suppressor gene product promotes apoptosis in various types of cells, we have investigated the expression of p53 in fetal gonads and
β¦ LIBER β¦
p53-dependent apoptosis is regulated by a C-terminally alternatively spliced form of murine p53
β Scribed by Almog, Nava; Goldfinger, Naomi; Rotter, Varda
- Book ID
- 110063996
- Publisher
- Nature Publishing Group
- Year
- 2000
- Tongue
- English
- Weight
- 256 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0950-9232
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## Abstract A p53 Cβterminal peptide (aa 361β382, p53p), fused at its Cβterminus to the minimal carrier peptide of __antennapedia__ (17 aa, Ant; p53pβAnt), induced rapid apoptosis in human cancer cells, __via__ activation of the Fas pathway. We examined p53pβAnt mechanism of action, toxicity in var