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p53 controls hPar1 function and expression

✍ Scribed by Salah, Z; Haupt, S; Maoz, M; Baraz, L; Rotter, V; Peretz, T; Haupt, Y; Bar-Shavit, R

Book ID
109970651
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
409 KB
Volume
27
Category
Article
ISSN
0950-9232

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The cyclin-dependent kinase inhibitor p21/WAF1 is regulated by p53-dependent and p53-independent pathways. In addition, p21/WAF1 binds with proliferating cell nuclear antigen (PCNA) and inhibits the action of PCNA. To investigate the possible role of p21/WAF1 in human hepatocellular carcinomas (HCCs