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p53 codon 72 polymorphism is linked to the development and not the progression of benign and malignant laryngeal tumours

✍ Scribed by G. Sourvinos; E. Rizos; D.A. Spandidos

Book ID: 114393752
Publisher: Elsevier Science
Year: 2001
Tongue: English
Weight: 690 KB
Volume: 37
Category: Article
ISSN: 1368-8375
DOI: 10.1016/s1368-8375(00)00139-1

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A polymorphism at codon 72 of the p53 gene, resulting in either an arginine or a proline residue in the protein, has been reported to affect the susceptibility of p53 to human papillomavirus (HPV) E6-mediated degradation in cultured cells. However, the relevance of this polymorphism to naturally occ