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P53 codon 72 polymorphism is associated with disease progression in adult T-cell leukaemia/lymphoma

✍ Scribed by Seisho Takeuchi; Masahide Matsushita; Kunihiro Tsukasaki; Naoko Takeuchi; Masao Tomonaga; Naoki Komatsu; Takayuki Ikezoe; Yoshio Uehara; H. P. Koeffler

Book ID: 108673481
Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 57 KB
Volume: 131
Category: Article
ISSN: 0007-1048
DOI: 10.1111/j.1365-2141.2005.05798.x

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## Abstract Human papillomavirus (HPV) infects the squamous epithelial cells of oral cavity and cervix leading to formation of warts that develops into the cancer. Human papillomavirus (HPV)‐16 and 18 encode E6 oncoprotein, which binds to and induces degradation of the tumour suppressor protein p53