Immunohistochemistry (IHC) is a cheap and rapid method to detect p53 inactivation but the results are often discordant with gene mutation analysis. This study aimed to investigate whether there is a difference in the immunohistochemical staining patterns of p53-positive cells on comparing tumours wi
p53 autoantibodies in sera of patients with a colorectal cancer and their association to p53 protein concentration and p53 immunohistochemistry in tumor tissue
✍ Scribed by R. Broll; M. Duchrow; E. Oevermann; C. Wellm; O. Schwandner; H. Schimmelpenning; U.J. Roblick; H.P. Bruch; U. Windhövel
- Publisher
- Springer
- Year
- 2001
- Tongue
- English
- Weight
- 62 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0179-1958
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## Abstract This study examined the sensitivity and specificity of serum auto‐antibodies to p53 protein as a non‐invasive marker of p53 genetic alterations or protein accumulation in lung cancer cases. A sensitive ELISA to detect serum p53 antibodies was developed and used to examine sera from 186