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p53 and Skin Carcinomas With Skull Base Invasion: A Case-Control Study

✍ Scribed by Claudio R. Cernea; Alberto R. Ferraz; Inês V. de Castro; Miriam N. Sotto; Ângela F. Logullo; Carlos E. Bacchi; André S. Potenza

Book ID
116811333
Publisher
SAGE Publications
Year
2006
Tongue
English
Weight
209 KB
Volume
134
Category
Article
ISSN
0194-5998

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Epidemiological data strongly implicate sunlight as the principal environmental cause of melanoma; however, critical molecular targets for ultraviolet (UV)-induced melanoma remain to be identified. The p53 tumor suppressor gene is one possible target, being abnormally expressed in 20-40% of primary