p53 and Retinoblastoma protein (pRb): A complex network of interactions
✍ Scribed by N. Godefroy; C. Lemaire; B. Mignotte; J.-L. Vayssière
- Book ID
- 106349440
- Publisher
- Springer
- Year
- 2006
- Tongue
- English
- Weight
- 203 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1360-8185
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Paraffin sections (n = 168, 27 benign, 16 low malignant potential [LMP] and 125 malignant tumours) from epithelial ovarian tumours were evaluated immunohistochemically for expression of retinoblastoma gene product (pRB) and p53 protein, and the relationship among pRB, p53 and cyclin-dependent kinase
## Abstract We recently characterized the interaction between poly(ADP‐ribose) polymerase‐1 (PARP‐1) and the product of the tumor suppressor gene __p53__. We investigated which domains of human PARP‐1 and of human wild‐type (wt) p53 were involved in this protein–protein interaction. We generated ba