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p53 and proliferating cell nuclear antigen expression in JC virus-infected cells of progressive multifocal leukoencephalopathy

✍ Scribed by Aurelio Ariza; JoséL. Mate; Angela Fernández-Vasalo; Carmen Gómez-Plaza; Javier Pérez-Piteira; Magda Pujol; JoséJ. Navas-Palacios

Book ID
116083515
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
696 KB
Volume
25
Category
Article
ISSN
1532-8392

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Progressive multifocal leukoencephalopathy (PML) is a lytic infection of oligodendrocytes by the human papovavirus JC. Patients with defects in cell-mediated immunity are at risk for active disease: a usually lethal demyelination of the brain. PML develops in at least 4% of patients with the acquire