p53 and p73: seeing double?
✍ Scribed by Soengas, María S; Lowe, Scott W
- Book ID
- 109829583
- Publisher
- Nature Publishing Group
- Year
- 2000
- Tongue
- English
- Weight
- 228 KB
- Volume
- 26
- Category
- Article
- ISSN
- 1061-4036
- DOI
- 10.1038/82497
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## Abstract Induction of apoptosis by the tumor suppressor p53 is known to protect from Myc‐driven lymphomagenesis. The p53 family member p73 is also a proapoptotic protein, which is activated in response to oncogenes like Myc. Here, we have investigated whether p73 provides a similar protection fr
## Abstract __p53__‐related genes, __p73__ and __p63__, encode 2 classes of proteins, TA‐p73/p63 and ΔN‐p73/p63. TA‐p73/p63 demonstrate p53‐like properties including gene transactivation and cell death promotion, whereas ΔN‐p73/p63 lack these p53‐like functions. Although p53‐deficient cancer cells