𝔖 Bobbio Scriptorium
✦   LIBER   ✦

p53 alterations in human leukemia–lymphoma cell lines: in vitroartifact or prerequisite for cell immortalization?

✍ Scribed by Drexler, H G; Fombonne, S; Matsuo, Y; Hu, Z-B; Hamaguchi, H; Uphoff, C C

Book ID
110054388
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
164 KB
Volume
14
Category
Article
ISSN
0887-6924

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Diethylstilbestrol-induced immortalizati
Diethylstilbestrol-induced immortalization of human endometrial cells: Alterations in p53 and estrogen receptor
✍ Clifford A. Rinehart; Li-hui Xu; Linda Van Le; David G. Kaufman 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 959 KB

carcinogenesis is a process requiring multiple steps. Immortalization is one step in this process and may be rate limiting. To ,further our understanding of estrogen-induced carcinogenesis, we evaluated diethylstilbestrol (DES)-induced irnmortalization of human endometrial stromal cells. This was ac

Mutation in p53 and de-regulation of p53
Mutation in p53 and de-regulation of p53-related gene expression in three human cell lines immortalized with 4-nitroquinoline 1-oxide or 60Co gamma rays
✍ Mikio Itjima; Koichiro Mihara; Tadashi Kondo; Toshiya Tsuji; Chikashi Ishioka; M 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 French ⚖ 739 KB

IMMORTALIZED In vitro models of malignant transformation of human cells may provide considerable insight into the mechanisms of multistep carcinogenesis. It is well established that normal human cells must be immortalized before they can be malignantly transformed; however, they are stringently dest

Abrogation of apoptosis induced by DNA-d
Abrogation of apoptosis induced by DNA-damaging agents in human bladder-cancer cell lines with p21/WAF1/CIP1 and/or p53 gene alterations
✍ Takashi Kawasaki; Yoshihiko Tomita; Vladimir Bilim; Masayuki Takeda; Kota Takaha 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 French ⚖ 570 KB

The p53-inducible cyclin-dependent kinase inhibitor, p2 I / WAFI/CIPI (p2I), plays a pivotal role in the GI arrest or apoptosis of cells expored to genotoxic stimuli. To determine whether p2 I is a putative tumor-suppressor gene, p2 I status was investigated in 4 human bladder-cancer cell lines of k