P53 accumulation in precursor lesions and early stages of bladder cancer
✍ Scribed by B. J. Schmitz-Dräger; C. R. C. Roeyen; M. O. Grimm; C. -D. Gerharz; K. Decken; W. A. Schulz; H. Bültel; D. Makri; T. Ebert; R. Ackermann
- Publisher
- Springer-Verlag
- Year
- 1994
- Tongue
- English
- Weight
- 525 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0724-4983
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Our aim was to determine whether the pattern of expression of the interrelated proteins p53, MDM2 and p21 could shed light on the etiopathogenic mechanisms of superficial bladder tumors. Protein expression was detected by immunohistochemistry (IHC) using monoclonal antibodies (MAbs) Pab 1801 for p53
## Abstract Overexpression of the nuclear phosphoprotein p53 is one of the most frequently detected abnormalities in human cancer and appears to be associated with mutation of the p53 gene. In this study of breast cancer, p53 overexpression was detected in two (15%) of 15 pure intraductal tumors, 7
We investigated if the presence of single nucleotide polymorphisms (SNPs) in the XRCC1, XRCC3, and XPD genes were associated with the type and frequency of p53 mutations in bladder cancer. Using a hospital-based case-control study we have previously reported risks for the XRCC1 codon 194, XRCC1 codo