P437 HESPERIDIN PREVENTS FIBROSIS BY DECREASING THE EXPRESSION OF NF-κB, TGF-β AND CTGF IN A CCl4-INDUCED LIVER DAMAGE IN RAT

Resveratrol prevents fibrosis, NF-κB act

Resveratrol prevents fibrosis, NF-κB activation and TGF-β increases induced by chronic CCl4 treatment in rats

✍ Enrique Chávez; Karina Reyes-Gordillo; José Segovia; Mineko Shibayama; Victor Ts 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 421 KB

## Abstract Resveratrol is a nonflavonoid polyphenol with antioxidant, anticancer and antiinflammatory properties. Moreover, it has been reported that this compound inhibits NF‐__κ__B, which regulates the transcription of several genes including cytokines such as the profibrogenic TGF‐__β__. The ai