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P4-386 The effect of simvastatin treatmnt the processing of the amyloid precursor protein in patients with Alzheimer's disease

✍ Scribed by Hoglund, Kina; Thelen, Karin M.; Syversen, Steinar; Sjogren, Magnus; von Bergmann, Klas; Wallin, Anders; Vanmechelen, Eugeen; Vanderstichele, Hugo; Luetjohann, Dieter; Blennow, Kaj

Book ID
123386474
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
164 KB
Volume
25
Category
Article
ISSN
0197-4580

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## Abstract Proteolytic processing of the amyloid precursor protein by Ξ² ‐and γ‐secretases results in the production of Alzheimer's disease (AD) AΞ² amyloid peptides. Modulation of secretase activity is being investigated as a potential therapeutic approach. Recent studies with human brain have reve