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P4-220 β-amyloid-induced inflammatory gene expression in human brain endothelial cells

✍ Scribed by Zhang, Wandong; Giuseppin, Sabina; Stanimirovic, Danica

Book ID: 123053212
Publisher: Elsevier Science
Year: 2004
Tongue: English
Weight: 320 KB
Volume: 25
Category: Article
ISSN: 0197-4580
DOI: 10.1016/S0197-4580(04)81778-0

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One of the pathological lesions in Alzheimer's disease (AD) is the amyloid or senile plaque. The plaque core is predominantly made up of amyloid beta peptide (AP), a 42-43 amino acid peptide derived from amyloid precursor protein (APP). APP is a membrane bound glycoprotein which is expressed ubiquit