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P4-122 Genetic association of an APP binding protein gene with late onset Alzheimer's disease

✍ Scribed by Li, Yonghong; Hollingworth, Paul; Moore, Pamela; Foy, Catherine; Archer, Nicola; Nowotny, Petra; Holmans, Peter; Smemo, Scott; Tacey, Kristina; Doil, Lisa; van Luchene, Ryan; Lau, Kit; Catanese, Joe; Garcia, Veronica; Rowland, Charlie; Sninsky, John; White, Tom; Hardy, John; Thal, Leon; Goate, Alison; Powell, John; Lovestone, Simon; Owen, Michael; Williams, Julie; Grupe, Andrew

Book ID
123361584
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
166 KB
Volume
25
Category
Article
ISSN
0197-4580

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Alzheimer disease (AD) is a complex neurodegenerative disorder predisposed by multiple genetic factors. Mutations in amyloid beta precursor protein (APP) are known to be associated with autosomal dominant, early onset familial AD and possibly also late onset AD (LOAD). A number of genes encoding pro