Pleural and pulmonary malignancies are usually associated with well-known carcinogen exposure. Recently, the presence of simian virus 40 (SV40)-like DNA sequences has been detected in brain and bone-related human cancers and in pleural mesothelioma. In order to determine whether SV40-like DNA sequen
P3D122 - SV40 virus-specific DNA sequences and etiology of malignant mesothelioma in Finland
β Scribed by A. Hirvonen; A. Karialainen; T. Ollikainen; L. Tammilehto; T. Hovi; K. Mattson; M. Carbone; K. Linnainmaa
- Book ID
- 119540462
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 140 KB
- Volume
- 95
- Category
- Article
- ISSN
- 0378-4274
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract The incidence of malignant mesothelioma (MM) shows a strong epidemiological association with exposure to asbestos fibers. Recently, simian virus 40 (SV40) DNA sequences have been reported in MM tumor specimens from the United States and several European countries, and the SV40 tumor vir
Occupational asbestos exposure can be demonstrated in 80% of mesothelioma cases. A possible role of simian virus 40 (SV40) in the etiology of mesothelioma was raised because several studies reported the presence and expression of SV40-like DNA sequences in human mesotheliomas. It is also known that
## Abstract In situ hybridization has been used as a quantitative method to study the replication of SV40 during lytic infection. Various parameters have been defined such as fixation and denaturation of cytological preparations, concentration of complementary (^3^H)βcRNA and volume of buffer used