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P3D122 - SV40 virus-specific DNA sequences and etiology of malignant mesothelioma in Finland

✍ Scribed by A. Hirvonen; A. Karialainen; T. Ollikainen; L. Tammilehto; T. Hovi; K. Mattson; M. Carbone; K. Linnainmaa


Book ID
119540462
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
140 KB
Volume
95
Category
Article
ISSN
0378-4274

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Pleural and pulmonary malignancies are usually associated with well-known carcinogen exposure. Recently, the presence of simian virus 40 (SV40)-like DNA sequences has been detected in brain and bone-related human cancers and in pleural mesothelioma. In order to determine whether SV40-like DNA sequen

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## Abstract The incidence of malignant mesothelioma (MM) shows a strong epidemiological association with exposure to asbestos fibers. Recently, simian virus 40 (SV40) DNA sequences have been reported in MM tumor specimens from the United States and several European countries, and the SV40 tumor vir

Simian virus 40 (SV40)–like DNA sequence
✍ Ari Hirvonen; Karin Mattson; Antti Karjalainen; Tiina Ollikainen; Lauri Tammileh πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 112 KB

Occupational asbestos exposure can be demonstrated in 80% of mesothelioma cases. A possible role of simian virus 40 (SV40) in the etiology of mesothelioma was raised because several studies reported the presence and expression of SV40-like DNA sequences in human mesotheliomas. It is also known that

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## Abstract In situ hybridization has been used as a quantitative method to study the replication of SV40 during lytic infection. Various parameters have been defined such as fixation and denaturation of cytological preparations, concentration of complementary (^3^H)‐cRNA and volume of buffer used