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P380 EXPRESSION OF THE FIBROBLAST GROWTH FACTOR 19 (FGF19) IN THE LIVER CORRELATES WITH CLINICAL AND LABORATORY MEASURES IN PATIENTS WITH PRIMARY BILIARY CIRRHOSIS

✍ Scribed by Wunsch, E.; Milkiewicz, M.; Kempińska-Podhorodecka, A.; Raszeja-Wyszomirska, J.; Trottier, J.; Barbier, O.; Milkiewicz, P.

Book ID
123544007
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
117 KB
Volume
60
Category
Article
ISSN
0168-8278

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Fibroblast growth factor 19 (FGF19) is an endocrine factor produced by the small intestine in response to uptake of luminal bile salts. In the liver, FGF19 binds to FGF receptor-4, resulting in down-regulation of cytochrome P (CYP) 7A1 and reduced bile salt synthesis. Down-regulation of CYP7A1 under