New cytotoxic agents are urgently needed for the treatment of advanced ovarian cancer because of the poor long-term response of this disease to conventional chemotherapy. Curcumin, obtained from the rhizome of Curcuma longa, has potent anticancer activity; however, the mechanism of curcumin-induced
โฆ LIBER โฆ
P38 Mitogen Activated Protein Kinase Is Involved in the Downregulation of Granulocyte CXC Chemokine Receptors 1 and 2 During Human Endotoxemia
โ Scribed by Bernt van den Blink; Judith Branger; Sebastiaan Weijer; Abhya Gupta; Sander J. H. van Deventer; Maikel P. Peppelenbosch; Tom van der Poll
- Book ID
- 111591937
- Publisher
- Springer
- Year
- 2004
- Tongue
- English
- Weight
- 55 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0271-9142
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## Abstract Blood vessel injury results in limited oxygen tension and diffusion leading to hypoxia, increased anaerobic metabolism, and elevated production of acidic metabolites that cannot be easily removed due to the reduced blood flow. Therefore, an acidic extracellular pH occurs in the local mi