p38 Mitogen-activated Protein Kinase Is Involved in H2O2-induced Phospholipase D Activation in Vascular Smooth Muscle Cells
β Scribed by Eung-Gook Kim; Eun-Young Shin; Do Sik Min; Byoung-Hee Park; Kyung-Sun Shin; Min-Soo Hyun; Ji-Cheol Shin; Hee-Yul Ahn; Roger J. Davis; Seung-Ryul Kim
- Book ID
- 110108292
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 101 KB
- Volume
- 928
- Category
- Article
- ISSN
- 0890-6564
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Bovine aortic smooth muscle cell (SMC) phenotype can be altered by physical forces. This has been demonstrated by cyclic strainβinduced changes in proliferation and alignment. However, the intracellular coupling pathways remain ill defined. In the present study, we examined whether the
Pyrrolidine dithiocarbamate (PDTC), a metal chelating compound, is known to induce cell death in vascular smooth muscle cells (VSMC). However, the molecular mechanism for PDTC-induced VSMC death is not well understood. Addition of PDTC reduced cell growth and DNA synthesis on VSMC in low density con