## Abstract The aim of the present study is to elucidate the signaling pathway involved in death of human neuroblastoma SKβNβSH cells induced by __Naja naja atra__ phospholipase A~2~ (PLA~2~). Upon exposure to PLA~2~, p38 MAPK activation, ERK inactivation, ROS generation, increase in intracellular
p38 MAPK activation and mitochondrial depolarization mediate the cytotoxicity of Taiwan cobra phospholipase A2 on human neuroblastoma SK-N-SH cells
β Scribed by Ku-Chung Chen; Pei-Hsiu Kao; Shinne-Ren Lin; Long-Sen Chang
- Book ID
- 119379870
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 579 KB
- Volume
- 180
- Category
- Article
- ISSN
- 0378-4274
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π SIMILAR VOLUMES
Taiwan cobra phospholipase A 2 (PLA 2 ) treatment promoted proADAM17 processing into mature ADAM17 in human neuroblastoma SK-N-SH cells. The abolishment of catalytic activity caused a drastic drop in the PLA 2 ability to induce ADAM17 maturation, and lysophosphatidylcholine treatment mimicked the ef
## Abstract The aim of the present study is to explore the signaling pathway associated with __Naja naja atra__ phospholipase A~2~ (PLA~2~)βinduced apoptotic death of human leukemia U937 cells. Degradation of procaspases, production of tBid, loss of mitochondrial membrane potential, and cytochrome