p38 MAP kinase enhances EGF-induced apoptosis in A431 carcinoma cells by promoting tyrosine phosphorylation of STAT1

Monolayer versus aggregate balance in su

Monolayer versus aggregate balance in survival process for EGF-induced apoptosis in A431 carcinoma cells: Implication of ROS-P38 MAPK-integrin α2β1 pathway

✍ Marie Morazzani; Daniela Diogenes de Carvalho; Herve Kovacic; Sophia Smida-Rezgu 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 French ⚖ 625 KB

## Abstract A431 cells escape EGF‐induced apoptosis by forming cell aggregates. We show that these clusters migrate and merge with neighboring ones, resulting in larger structures composed of a multilayer central (3D) population surrounded by a cell monolayer (2D). We found that after 48 hr of 10 n