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P362 HYPOXIA UP-REGULATES FIBULIN-5 IN ENDOTHELIAL CELLS THROUGH A HIF-1 DEPENDENT MECHANISM

✍ Scribed by Guadall, A.; Rodríguez-Calvo, R.; Aledo, R.; Calvayrac, O.; Martínez-González, J.; Rodríguez, C.

Book ID: 118638435
Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 82 KB
Volume: 11
Category: Article
ISSN: 1567-5688
DOI: 10.1016/s1567-5688(10)70429-3

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## Abstract Angiopoietins are ligands of the endothelial cell tyrosine kinase receptor Tie2. Angiopoietin‐1 (Ang‐1) is widely expressed in human normal adult tissues and promotes blood vessel maturation and stabilization by inducing Tie2 receptor phosphorylation. In contrast, the antagonistic ligan