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P33. Expression of alpha v beta 3 integrin in patients with high and low grade glioma

✍ Scribed by O. Schnell; B. Krebs; E. Wagner; A.J. Beer; S.J. Grau; C. Goetz; H.A. Kretzschmar; R.H. Goldbrunner; J.C. Tonn

Book ID
119233527
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
56 KB
Volume
4
Category
Article
ISSN
1359-6349

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## Abstract ## BACKGROUND Two families of tumor suppressor genes, Cip/Kip (p21, p27, and 57) and INK4 (p15, p16, p18, and p19), regulate cell proliferation and neoplastic transformation. p27 exerts its suppressor effect through cyclin E‐dependent kinase (CDK2) by inhibiting the phosphorylation of