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P2X7 Receptor-Mediated Disruption of the Plasma Membrane and Endoplasmic Reticulum Morphology and Cell Survival

✍ Scribed by Tomic, Melanija; Yan, Zonghe; Li, Suo; Sherman, Arthur; Stojilkovic, Stanko S.

Book ID
122201445
Publisher
Biophysical Society
Year
2010
Tongue
English
Weight
84 KB
Volume
98
Category
Article
ISSN
0006-3495

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## Abstract P2X7 receptor (P2X7R) activation by extracellular ATP triggers influx of Na^+^ and Ca^2+^, cytosolic Ca^2+^ overload and consequently cytotoxicity. Whether disturbances in endoplasmic reticulum (ER) Ca^2+^ homeostasis and ER stress are involved in P2X7R‐mediated cell death is unknown. I