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P2X2 knockout mice and P2X2/P2X3 double knockout mice reveal a role for the P2X2 receptor subunit in mediating multiple sensory effects of ATP

✍ Scribed by Debra A. Cockayne; Philip M. Dunn; Yu Zhong; Weifang Rong; Sara G. Hamilton; Gillian E. Knight; Huai-Zhen Ruan; Bei Ma; Ping Yip; Philip Nunn; Stephen B. McMahon; Geoffrey Burnstock; Anthony P. D. W. Ford

Book ID
110113432
Publisher
Cambridge University Press
Year
2005
Tongue
English
Weight
560 KB
Volume
567
Category
Article
ISSN
0022-3751

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## Abstract ATP is the dominant messenger for astrocyte‐to‐astrocyte calcium‐mediated communication. Definition of the exact ATP/P2 receptors in astrocytes and of their coupling to intracellular calcium ([Ca^2+^]~i~) has important implications for brain physiology and pathology. We show that, with