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P.2.c.024 Impact of polymorphism of cytochrome P450 2D6 on clinical effects of mirtazapine

✍ Scribed by J. Kim; M. Lee


Book ID
118593944
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
55 KB
Volume
17
Category
Article
ISSN
0924-977X

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The interaction of antiparasitic drugs with the polymorphic cytochrome P450 2D6 was studied in human liver microsomes. Of ten different drugs tested, three quinolines, oxamniquine, primaquine and chloroquine inhibited microsomal CYP2D6-catalysed formation of l'hydroxybufuralol at concentrations tha