Homology modeling and substrate binding
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Vilia Ann Payne; Yan-Tyng Chang; Gilda H. Loew
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Article
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1999
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John Wiley and Sons
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English
β 583 KB
It is well established that the variable binding-site architecture and composition of the P450 metabolizing heme proteins are major modulators of substrate and product specificity. Even the three closely related human liver isozymes, CYP2C9, CYP2C18, and CYP2C19, do not share all substrates and do n