P294 Merkel cell tumor
✍ Scribed by J. Pereda; E. Abbad; J. Ruffin; S. Ortiz; J.R. Ramírez; M. Remezal
- Book ID
- 118604732
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 129 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0926-9959
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The clinical courses of six patients treated with cytotoxic chemotherapy for recurrent Merkel cell tumor of the skin are reported. All patients experienced prompt clinical responses to chemotherapy (five complete response [CR], one partial response [PR]) and three patients (50%) have achieved long-t
## Abstract Most Merkel cell carcinomas (MCCs) contain Merkel cell polyomavirus (MCPyV) DNA, and the virus likely has a pivotal role in tumor pathogenesis. p53 and the KIT receptor tyrosine kinase have also been implicated in MCC pathogenesis, but little is known about their association with MCPyV