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p27Kip1 loss does not predict survival in patients with advanced gastric carcinoma

โœ Scribed by Roger M. Feakins; Hugh E. Mulcahy; Alberto Quaglia; Aida Jawhari; Zunwu Zhang; Stephen E. Patchett

Book ID
102670735
Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
535 KB
Volume
89
Category
Article
ISSN
0008-543X

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BACKGROUND. p27 Kip1 is a cyclin-dependent kinase inhibitor and is a potential tumor suppressor gene. Reduced expression of p27 Kip1 is a powerful negative prognostic marker in primary lung, breast, colon, bladder, and prostate carcinomas. In the current study, the prognostic value of p27 Kip1 in ga

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## RESULTS. Various levels of p21 and p53 immunoreactivities in carcinoma cells were detected in 30 (32%) and 60 (65%), respectively, of 93 samples. There was no 1 First Department of Pathology, Faculty of Medcorrelation between p21 and p53 expression. The 5-year survival rate of patients icine, T