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p27Kip1 expression in normal epithelia, precancerous lesions, and carcinomas of the gallbladder: Association with cancer progression and prognosis

โœ Scribed by Ai-Min Hui; Xin Li; Ya-Zhou Shi; Guido Torzilli; Tadatoshi Takayama; Masatoshi Makuuchi

Book ID
111720701
Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
283 KB
Volume
31
Category
Article
ISSN
0270-9139

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## Abstract ## Background and Objectives Low tumor expression of the p27^Kip1^ protein, which is involved in cell cycle control and apoptosis, is considered a negative prognostic factor in different types of cancer. The aim of this study was to evaluate the clinical and pathological significance o

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Expression of p27Kip1 and cyclin D1 proteins is inversely correlated and is associated with poor clinical outcome in human gastric cancer
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Background and Objectives: p27Kip1 is an inhibitor of cyclindependent kinases and is speculated to be a potential prognostic indicator in numerous human cancers. We investigated expression of p27Kip1 along with cyclin D1 in gastric cancer to estimate the clinical utility of p27Kip1. Methods: Immunoh