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p27Kip1 alters the response of cells to mitogen and is part of a cell-intrinsic timer that arrests the cell cycle and initiates differentiation

✍ Scribed by Béatrice Durand; Matthew L. Fero; James M. Roberts; Martin C. Raff

Book ID: 114321096
Publisher: Elsevier Science
Year: 1998
Tongue: English
Weight: 261 KB
Volume: 8
Category: Article
ISSN: 0960-9822
DOI: 10.1016/s0960-9822(98)70177-0

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## Abstract ## BACKGROUND Low levels of p27^Kip1^ are associated with high aggressiveness and poor prognosis in various malignancies, including colorectal carcinoma. The authors showed that S phase kinase protein 2 (Skp2), the specific ubiquitin ligase subunit that targets p27^Kip1^ for degradatio