𝔖 Bobbio Scriptorium
✦   LIBER   ✦

p27 Kip1 inhibits HER2/neu-mediated cell growth and tumorigenesis

✍ Scribed by Yang, Heng-Yin; Shao, Ruping; Hung, Mien-Chie; Lee, Mong-Hong


Book ID
110064748
Publisher
Nature Publishing Group
Year
2001
Tongue
English
Weight
289 KB
Volume
20
Category
Article
ISSN
0950-9232

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


Modified p27 Kip1 is efficient in suppre
✍ Heng-Yin Yang; Huiling Yang; Ruiying Zhao; Mong-Hong Lee πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 English βš– 384 KB

Cyclin-dependent kinase (CDK) inhibitor p27 Kip1, a haplo-insufficient tumor suppressor, is downregulated by oncogenic signal of HER2, a receptor tyrosine kinase oncogene. HER2 promotes mitogenic growth and transformation of cancer cells. HER2 signaling can enhance p27 Kip1 ubiquitination, thereby p

p27/Kip1 mediates retinoic acid-induced
✍ Scott Vuocolo; Dianne Robert Soprano; Kenneth J. Soprano πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 184 KB

## Abstract We have investigated the mechanisms by which all‐trans retinoic acid (ATRA) causes growth inhibition of ovarian carcinoma cells. As a model, we have studied the CAOV3 cell line, which is sensitive to ATRA, and the SKOV3 cell line, which is resistant. We have found that treatment of CAOV

Sequence requirement for nuclear localiz
✍ Katsuya Hirano; Ying Zeng; Mayumi Hirano; Junji Nishimura; Hideo Kanaide πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 English βš– 336 KB

## Abstract p27^Kip1R^ is an isoform of p27^Kip1^, having a distinct C‐terminus. The sequences of p27^Kip1R^ required for nuclear localization and growth inhibition were determined in HeLa cells using a green fluorescence protein (GFP) as a reporter molecule. Region 153–168 and residues K168 and I1

Enhancement of the p27Kip1-mediated anti
✍ Radu Marches; Jonathan W. Uhr πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 French βš– 578 KB

## Abstract The oncogenic activity of the overexpressed HER2 tyrosine kinase receptor requires its localization in the plasma membrane. The antitumor effect of anti‐HER2 antibodies (Abs) is mainly dependent on receptor downregulation and comprises p27^Kip1^‐mediated G~1~ cell cycle arrest. However,