p27 Kip1 inhibits HER2/neu-mediated cell growth and tumorigenesis
β Scribed by Yang, Heng-Yin; Shao, Ruping; Hung, Mien-Chie; Lee, Mong-Hong
- Book ID
- 110064748
- Publisher
- Nature Publishing Group
- Year
- 2001
- Tongue
- English
- Weight
- 289 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0950-9232
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Cyclin-dependent kinase (CDK) inhibitor p27 Kip1, a haplo-insufficient tumor suppressor, is downregulated by oncogenic signal of HER2, a receptor tyrosine kinase oncogene. HER2 promotes mitogenic growth and transformation of cancer cells. HER2 signaling can enhance p27 Kip1 ubiquitination, thereby p
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## Abstract p27^Kip1R^ is an isoform of p27^Kip1^, having a distinct Cβterminus. The sequences of p27^Kip1R^ required for nuclear localization and growth inhibition were determined in HeLa cells using a green fluorescence protein (GFP) as a reporter molecule. Region 153β168 and residues K168 and I1
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