Early Structural and Functional Changes
Early Structural and Functional Changes in Liver of Rats Treated with a Single Dose of Valproic Acid
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Anne Marie Jezequel; Patrizia Bonazzi; Giuseppe Novelli; Cinzia Venturini; Franc
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Article
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1984
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John Wiley and Sons
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English
⚖ 891 KB
Valproic acid (VPA) is a simple fatty acid largely used as anticonvulsivant agent. Side effects are uncommon, but cases of fatal hepatic failure have been reported. To elucidate the mechanism of VPA-induced hepatotoxicity, the functional and structural changes associated with administration of sodiu