p21WAF1/CIP1 response to genotoxic agents in wild-type TP53 expressing breast primary tumours
✍ Scribed by Guillot, Céline; Falette, Nicole; Paperin, Marie-Pierre; Courtois, Stéphanie; Gentil-Perret, Anne; Treilleux, Isabelle; Ozturk, Mehmet; Puisieux, Alain
- Book ID
- 110060469
- Publisher
- Nature Publishing Group
- Year
- 1997
- Tongue
- English
- Weight
- 973 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0950-9232
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Mutations in the p53 tumour suppressor gene are the most common genetic alteration found in human cancers. Most of them are accompanied by stabilization of the protein, which renders it detectable through immunohistochemical techniques. Although p53 expression is a very common finding in Hodgkin's d
Recently, we demonstrated that downregulation of inosine-5-monophosphate dehydrogenase (IMPD; IMP:NAD oxidoreductase, EC 1.2.1.14), the rate-limiting enzyme for guanine nucleotide biosynthesis, is required for p53-dependent growth suppression. These studies were performed with cell lines derived fro