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p21WAF1/CIP1 expression in gestational trophoblastic disease: correlation with clinicopathological parameters, and Ki67 and p53 gene expression

✍ Scribed by Cheung, A. N.; Shen, D. H.; Khoo, U. S.; Wong, L. C.; Ngan, H. Y.

Book ID
121758895
Publisher
BMJ Publishing Group
Year
1998
Tongue
English
Weight
175 KB
Volume
51
Category
Article
ISSN
0021-9746

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Defects in the mechanisms controlling the cell cycle are crucial in cell transformation and/or tumour progression. p21 WAF1/CIP1 is an inhibitor of cyclin-dependent kinases, induced by p53-dependent and p53-independent pathways, which can block progression through the cell cycle. p21 WAF1/CIP1 expre