Cardinal symptoms of Parkinson's disease (PD) respond well to treatment with levodopa and deep brain stimulation (DBS) of the subthalamic nucleus (STN). However, it has remained unclear whether levodopa and STN-DBS have differential effects on bradykinesia. We investigated 8 PD-patients with STN-ele
P2.134 Differential response of bradykinesia and hypokinesia to levodopa in Parkinson's disease
โ Scribed by A. Espay; J. Giuffrida; R. Chen; J. Vaughan; A. Duker; D. Heldman
- Book ID
- 117753688
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 58 KB
- Volume
- 15
- Category
- Article
- ISSN
- 1353-8020
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## Abstract In this prospective study of 34 patients with Parkinson's disease, measurements of the short duration levodopa motor response have been performed in defined __off__ states at 3 yearly intervals over a mean period of 11.4 years from the point of commencement of levodopa treatment. Twenty
In 92 parkinsonian patients (42 men, 50 women) aged from 37-79 years (mean 62.8) the impact of cerebral atrophy as assessed by computed tomography on the course of the clinical symptomatology under levodopa during a period of 1 to 5 years was investigated. It could be shown that patients suffering f