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P21 RNA and protein expression in non-small cell lung carcinomas: Evidence of p53-independent expression and association with tumoral differentiation


Book ID
123193606
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
130 KB
Volume
16
Category
Article
ISSN
0169-5002

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We examined the p53 status of 108 NSCLCs compared to the expression of MLH1 and MSH2 proteins. p53 overexpression was demonstrated by IHC in 64% of patients examined, whereas p53 mutations were detected in 43%. Twenty-two percent of mutations were located outside of the hot-spot (exons 5-8) area. p5