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p21 gene codon 31 polymorphism is associated with bladder cancer

✍ Scribed by Wen-Chi Chen; Hsi-Chin Wu; Cheng-Der Hsu; Huey-Yi Chen; Fuu-Jen Tsai

Book ID
117724158
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
254 KB
Volume
7
Category
Article
ISSN
1078-1439

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## Abstract Background p21 (WAF1/CIP1) is a downstream protein from p53 and can arrest the cell cycle at the G1/S phase in response to signal from p53. The most frequently seen polymorphic site is at codon 31, where a base change from AGC to AGA causes an amino acid change from serine to arginine.