Defects in the mechanisms controlling the cell cycle are crucial in cell transformation and/or tumour progression. p21 WAF1/CIP1 is an inhibitor of cyclin-dependent kinases, induced by p53-dependent and p53-independent pathways, which can block progression through the cell cycle. p21 WAF1/CIP1 expre
p21 Expression in colorectal carcinomas: a study on 103 cases with analysis of p53 gene mutation/expression and clinic-pathological correlations
โ Scribed by S. Girlando; P. Slomp; O. Caffo; M. Amichetti; R. Togni; G. Dvornik; L. Tomio; E. Galligioni; P. Dalla Palma; M. Barbareschi
- Publisher
- Springer
- Year
- 1999
- Tongue
- English
- Weight
- 347 KB
- Volume
- 435
- Category
- Article
- ISSN
- 1432-2307
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
p2lCipl was first isolated as one of the cyclin-dependent kinase (Cdk) interacting proteins induced by wild-type p53 gene product, and it appears to play an essential regulatory role in the control of cell proliferation as a potent, tight-binding inhibitor of cyclin-Cdk complex that blocks the G,/S
The tissues from 70 Chinese patients with oesophageal squamous cell carcinoma were prospectively collected to study for the pattern of p53 mutations and its relationship with clinico-pathological features and prognosis using immunohistochemistry, polymerase chain reaction-single strand conformationa
## Abstract Routine pathological examination cannot distinctively predict the clinical course of meningiomas because even histologically benign tumors may recur after gross total resection. Numerous efforts have been made for the evaluation of different immunohistochemical assays in meningioma prog
Sixty-six unselected breast cancers were analyzed in cytologic smears and histologic sections for the expression of proliferating cell nuclear antigen (PCNA), estrogen receptor protein (ERP), and p53 protein using a standard immunochemical method. The results, expressed as both positive cases and la