## Abstract ## Objective To examine the pathogenetic mechanisms of osteoarthritis (OA)โlike changes in Col9a1^โ/โ^ mice, which are deficient in type IX collagen. ## Methods Knee joints and temporomandibular joints (TMJs) from Col9a1^โ/โ^ mice and their wildโtype (Col9a1^+/+^) littermates were ex
โฆ LIBER โฆ
P203 Altered mechanical function coincident with osteoarthritis-like changes in knee joints of type IX collagen-deficient mice
- Book ID
- 114349147
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 116 KB
- Volume
- 13
- Category
- Article
- ISSN
- 1063-4584
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## Abstract ## Objective To investigate whether heterozygosity for a lossโofโfunction mutation in the gene encoding the ฮฑ1 chain of type XI collagen (__Col11a1__) in mice (chondrodysplasia, __cho__) causes osteoarthritis (OA), and to understand the biochemical and biomechanical effects of this mut