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P2 receptors and neuronal injury

✍ Scribed by Heike Franke; Ute Krügel; Peter Illes

Publisher: Springer
Year: 2006
Tongue: English
Weight: 483 KB
Volume: 452
Category: Article
ISSN: 0031-6768
DOI: 10.1007/s00424-006-0071-8

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## Abstract The P2X~7~ receptor has been implicated in the release of cytokines and in the induction of cell death, and is up‐regulated in a transgenic mouse model of Alzheimer's disease. Using cocultures of rat cortical neurons and microglia, we show that ATP and the more potent P2X~7~ agonist ben